ES8306476A1 - Derivados de guanidina. - Google Patents
Derivados de guanidina.Info
- Publication number
- ES8306476A1 ES8306476A1 ES510583A ES510583A ES8306476A1 ES 8306476 A1 ES8306476 A1 ES 8306476A1 ES 510583 A ES510583 A ES 510583A ES 510583 A ES510583 A ES 510583A ES 8306476 A1 ES8306476 A1 ES 8306476A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- radical
- compound
- values given
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8108407 | 1981-03-18 | ||
| GB8132680 | 1981-10-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES510583A0 ES510583A0 (es) | 1983-06-01 |
| ES8306476A1 true ES8306476A1 (es) | 1983-06-01 |
Family
ID=26278795
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510583A Expired ES8306476A1 (es) | 1981-03-18 | 1982-03-18 | Derivados de guanidina. |
| ES519401A Granted ES519401A0 (es) | 1981-03-18 | 1983-01-31 | Procedimiento para preparar derivados de guanidina. |
| ES519403A Granted ES519403A0 (es) | 1981-03-18 | 1983-01-31 | Procedimiento para preparar derivados de guanidina. |
| ES519402A Expired ES8406424A1 (es) | 1981-03-18 | 1983-01-31 | Procedimiento para preparar derivados de guanidina. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519401A Granted ES519401A0 (es) | 1981-03-18 | 1983-01-31 | Procedimiento para preparar derivados de guanidina. |
| ES519403A Granted ES519403A0 (es) | 1981-03-18 | 1983-01-31 | Procedimiento para preparar derivados de guanidina. |
| ES519402A Expired ES8406424A1 (es) | 1981-03-18 | 1983-01-31 | Procedimiento para preparar derivados de guanidina. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4795755A (en]) |
| EP (1) | EP0060697B1 (en]) |
| AU (1) | AU556079B2 (en]) |
| CA (1) | CA1200549A (en]) |
| DD (1) | DD202552A5 (en]) |
| DE (1) | DE3274856D1 (en]) |
| DK (1) | DK121282A (en]) |
| ES (4) | ES8306476A1 (en]) |
| FI (1) | FI820882L (en]) |
| GR (1) | GR76470B (en]) |
| IE (1) | IE52764B1 (en]) |
| IL (1) | IL65160A (en]) |
| IN (1) | IN158869B (en]) |
| NO (1) | NO820870L (en]) |
| NZ (1) | NZ200042A (en]) |
| PL (1) | PL137088B1 (en]) |
| PT (1) | PT74599B (en]) |
| ZW (1) | ZW3682A1 (en]) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1233818A (en) * | 1981-03-09 | 1988-03-08 | David J. Gilman | Guanidine derivatives as histamine h-2 receptor antagonists |
| CA1211111A (en) * | 1982-02-15 | 1986-09-09 | Isao Yanagisawa | Process for preparing novel pyrimidone compounds |
| US4808589A (en) * | 1982-02-20 | 1989-02-28 | Smith Kline & French Laboratories Limited | Pyrimidone derivatives |
| GB8316779D0 (en) * | 1982-09-07 | 1983-07-27 | Ici Plc | Process |
| US4585781A (en) * | 1982-12-31 | 1986-04-29 | Glaxo Group Limited | Heterocyclic derivatives |
| GB8401751D0 (en) * | 1984-01-24 | 1984-02-29 | Ici Plc | Guanidine derivatives |
| GB8421427D0 (en) * | 1984-08-23 | 1984-09-26 | Smith Kline French Lab | Chemical compounds |
| WO1994026715A1 (en) * | 1993-05-11 | 1994-11-24 | Smithkline Beecham Plc | Amidine derivatives as gastric acid secretion inhibitors |
| WO2013134562A1 (en) | 2012-03-09 | 2013-09-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| KR102300675B1 (ko) | 2012-12-20 | 2021-09-13 | 템페스트 테라퓨틱스, 인코포레이티드 | 트리아졸론 화합물 및 이의 용도 |
| MX2016002795A (es) | 2013-09-06 | 2016-05-26 | Inception 2 Inc | Compuestos de triazolona y usos de los mismos. |
| WO2022034121A1 (en) | 2020-08-11 | 2022-02-17 | Université De Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE866155A (fr) * | 1977-04-20 | 1978-10-19 | Ici Ltd | Nouveaux derives de la guanidine |
| GR62452B (en) * | 1977-04-20 | 1979-04-12 | Ici Ltd | Preparation process of guanidine derivatives |
| GB2001624B (en) * | 1977-04-20 | 1982-03-03 | Ici Ltd | Guanidine derivatives processes for their manufacture and pharmaceutical compositions containing them |
| US4165378A (en) * | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| JPS5444660A (en) * | 1977-08-29 | 1979-04-09 | Yamanouchi Pharmaceut Co Ltd | Heterocyclic compound and its preparation |
| DE2835695A1 (de) * | 1977-08-29 | 1979-03-15 | Yamanouchi Pharma Co Ltd | Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten |
| DE2961923D1 (en) * | 1978-01-18 | 1982-03-11 | Ici Plc | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| EP0006679B1 (en) * | 1978-05-24 | 1982-07-21 | Imperial Chemical Industries Plc | Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| EP0014057B1 (en) * | 1979-01-18 | 1985-01-02 | Imperial Chemical Industries Plc | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| JPS6056143B2 (ja) * | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | アミジン誘導体ならびにその製造法 |
| PH16099A (en) * | 1979-03-06 | 1983-06-24 | Yamanouchi Pharma Co Ltd | Guanidinothiazole compounds,process for preparing them and medical composition containing them |
| US4242351A (en) * | 1979-05-07 | 1980-12-30 | Imperial Chemical Industries Limited | Antisecretory oxadiazoles and pharmaceutical compositions containing them |
| GR71929B (en]) * | 1979-11-13 | 1983-08-19 | Ici Ltd | |
| FI73423C (fi) * | 1980-02-29 | 1987-10-09 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av farmakologiskt verksamma tetrazolderivat. |
| DE3168031D1 (en) * | 1980-07-30 | 1985-02-14 | Ici Plc | Guanidine derivatives |
| GB2085871B (en) * | 1980-08-08 | 1984-07-25 | Kotobuki Seiyaku Co Ltd | New 3-substituted-2-propenimidamides and method of manufacturing the same |
| EP0050407A1 (en) * | 1980-08-27 | 1982-04-28 | Glaxo Group Limited | 3,5-Disubstituted-1,2,4-triazole compounds, processes for their preparation and pharmaceutical compositions containing them |
-
1982
- 1982-02-23 IN IN149/DEL/82A patent/IN158869B/en unknown
- 1982-02-24 IE IE394/82A patent/IE52764B1/en unknown
- 1982-02-26 ZW ZW36/82A patent/ZW3682A1/xx unknown
- 1982-03-01 US US06/353,384 patent/US4795755A/en not_active Expired - Fee Related
- 1982-03-03 IL IL65160A patent/IL65160A/xx unknown
- 1982-03-04 AU AU81137/82A patent/AU556079B2/en not_active Ceased
- 1982-03-08 GR GR67523A patent/GR76470B/el unknown
- 1982-03-12 EP EP82301279A patent/EP0060697B1/en not_active Expired
- 1982-03-12 DE DE8282301279T patent/DE3274856D1/de not_active Expired
- 1982-03-15 FI FI820882A patent/FI820882L/fi not_active Application Discontinuation
- 1982-03-15 PL PL1982235453A patent/PL137088B1/pl unknown
- 1982-03-17 DD DD82238231A patent/DD202552A5/de unknown
- 1982-03-17 PT PT74599A patent/PT74599B/pt unknown
- 1982-03-17 CA CA000398640A patent/CA1200549A/en not_active Expired
- 1982-03-17 NZ NZ200042A patent/NZ200042A/en unknown
- 1982-03-17 NO NO820870A patent/NO820870L/no unknown
- 1982-03-18 DK DK121282A patent/DK121282A/da not_active Application Discontinuation
- 1982-03-18 ES ES510583A patent/ES8306476A1/es not_active Expired
-
1983
- 1983-01-31 ES ES519401A patent/ES519401A0/es active Granted
- 1983-01-31 ES ES519403A patent/ES519403A0/es active Granted
- 1983-01-31 ES ES519402A patent/ES8406424A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI820882A7 (fi) | 1982-09-19 |
| IE820394L (en) | 1982-09-18 |
| NO820870L (no) | 1982-09-20 |
| IN158869B (en]) | 1987-02-07 |
| DE3274856D1 (en) | 1987-02-05 |
| FI820882L (fi) | 1982-09-19 |
| CA1200549A (en) | 1986-02-11 |
| ES510583A0 (es) | 1983-06-01 |
| ES8403440A1 (es) | 1984-03-16 |
| ES519401A0 (es) | 1984-03-16 |
| DD202552A5 (de) | 1983-09-21 |
| NZ200042A (en) | 1985-08-30 |
| IL65160A (en) | 1986-04-29 |
| US4795755A (en) | 1989-01-03 |
| ES519402A0 (es) | 1984-07-16 |
| ES8403441A1 (es) | 1984-03-16 |
| GR76470B (en]) | 1984-08-10 |
| EP0060697B1 (en) | 1986-12-30 |
| PL137088B1 (en) | 1986-04-30 |
| AU8113782A (en) | 1982-09-23 |
| IE52764B1 (en) | 1988-02-17 |
| PT74599B (en) | 1983-11-07 |
| ZW3682A1 (en) | 1983-10-26 |
| PT74599A (en) | 1982-04-01 |
| AU556079B2 (en) | 1986-10-23 |
| EP0060697A1 (en) | 1982-09-22 |
| ES519403A0 (es) | 1984-03-16 |
| DK121282A (da) | 1982-09-19 |
| PL235453A1 (en) | 1983-03-28 |
| ES8406424A1 (es) | 1984-07-16 |
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